![]() There are a number of potential side effects in currently available anti-diabetic treatments. have reported that the efficacy of anti-diabetic drugs in achieving optimal glycemic control was only 41% among patients. Although many new OHAs have been developed, there remain some disadvantages of current treatments. Pharmacological intervention, including oral hypoglycemic agents (OHA) and insulin, is recommended for patients who are unable to reach their glycemic goals by lifestyle modification. Controlling blood glucose level in people with diabetes will help reduce morbidity and mortality globally. It is responsible for over 5 million deaths. Diabetes is an important risk factor for cardiovascular disease and chronic kidney disease. There are more than 415 million people with diabetes in the world, and the number will be 642 million by 2040. The dosage and treatment duration of Berberine and patients’ age may modify the effect.ĭIABETES MELLITUS, a metabolic disorder of the endocrine system, is one of the most common chronic diseases worldwide. The efficiency of Berberine combined with hypoglycaemics is better than either Berberine or hypoglycaemic alone. Subgroup-analyses indicated that effects of Berberine on blood glucose became unremarkable as the treatment lasted more than 90 days, the daily dosage more than 2 g/d and patients aged more than 60 years. The pool data showed that Berberine treatment was associated with a better reduction on FPG (WMD = –0.54 mmol/L, 95% CI: –0.77 to –0.30), PPG (WMD = –0.94 mmol/L, 95% CI: –1.27 to –0.61), and HbA1c (WMD = –0.54 mmol/L, 95% CI: –0.93 to –0.15) than control groups. Twenty-eight studies were identified for analysis, with a total of 2,313 type 2 diabetes mellitus (T2DM) patients. ![]() We calculated weighted mean differences (WMD) and 95% confidence interval (CI) for fasting plasma glucose (FPG), postprandial plasma glucose (PPG) and glycated haemoglobin (HbA1c) levels. We searched PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, and Wanfang Database to identify randomized controlled trials that investigated the effect of Berberine. We conducted a systematic review and meta-analysis to evaluate the effect of Berberine on glucose in patients with type 2 diabetes mellitus and identify potential factors may modifying the hypoglycemic effect.
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